Here, in Nivelles (Belgium), you will join a collaborative team full of passionate change-makers and be a key contributor to the successful development of an innovative RNA production platform. You will design a high-performance manufacturing process in collaboration with internal and external experts and identify opportunities for incremental or fundamental improvement. You will help our equipment engineering team in designing and developing a next-generation manufacturing system aimed at improving affordable access to RNA-based medicines. 

RESPONSIBILITIES 

  • Develop new manufacturing concepts for production of RNA-based medicines and other processes based on in vitro reactions (cell-free synthesis of biological molecules);
  • Provide tactical and scientific leadership of platform development projects, either of the entire project (USP, DSP, assay development, manufacturing equipment) or of a project subteam (USP) – this includes (non-exhaustively):
    • Prepare, or support the preparation of the platform development plan;
    • Prepare operational and scientific plans using best-practice approaches and supervise their implementation (or contribute to their execution, as appropriate);
    • Streamline and integrate workflows within different subteams for a synchronized and uninterrupted progress of the development project towards predefined objectives (in close collaboration with the Project Manager);
    • Ensure readiness and continuity for project operations (facilities, equipment, reagent and consumable stocks, access to service providers…);
    • Ensure all work is accurately and comprehensively documented, in a timely fashion and following corporate procedures and templates;
    • Promote innovation and develop promising ideas to proof-of-concept, and support patent applications when requested; 
    • Prepare project summaries and updates for presentation to the company’s management team, as needed;
  • Closely monitor the state-of-the-art in the field of molecular biology (applications relevant to the company’s projects) and report significant updates to peers and the company’s leadership;
  • Act as subject matter expert for the Innovation Team and the company (peer training, counsel, due diligence support…);
  • The ideal candidate also has experience in a different field of science, ideally in an industry setting, e.g. mammalian cell culture, fermentation, analytical sciences, purification.

REQUIREMENTS / QUALIFICATIONS

  • PhD in Molecular Biology, or Master’s degree with proven track record in Research & Development 
  • Experience in genetic engineering and plasmid design (including optimization of the coding sequence)
  • At least 3 years (PhD) or 8 years (Master) of experience in an industry R&D setting   
  • Prior experience with RNA synthesis processes is a significant plus
  • R&D experience in other scientific fields (cell culture, analytical development, purification) is a significant plus
  • Innovative mindset / scientific creativity: natural inclination to challenge the status quo and ability to conceptualize feasible process improvements (both evolutions and revolutions)
  • Knowledge of statistical design of experiments is an asset
  • Ability to work independently in a high-paced and fast-changing environment
  • Analytical mindset
  • Strong organizational and leadership skills
  • Ability to work in a cross-functional and multi-cultural team
  • Fluent in English (written and spoken); knowledge of French is an asset