Bringing viral production to the next level
The scale-X™ bioreactor portfolio provides enhanced upstream processing of viral products. Featuring a structured and intensified fixed-bed design, scale-X bioreactors are chained with in-line product concentration. It offers a linear scalability from the bench to the plant (R&D to commercial), perfectly suited to deliver your viral vaccines and gene therapies.
Overcoming the main challenges of biomass immobilization
Inhomogeneous cell distribution caused by unstructured fixed-bed designs (strips, discs)
Homogeneous cell and media distribution throughout the fixed-bed
- Patented spiral-wound structured fixed-bed
- Homogeneous and reproducible cell growth performance
Difficult scaling from the bench to the plant
Smooth, de-risked scale-up and scale-down
- Comprehensive portfolio covering R&D, clinical and commercial needs
- Linear scalability by design
Large process footprints and complex operations
Low-footprint and concentrated harvests
- Bioreactor chained with in-line product concentration
- Simplified upstream and downstream processing
Viral vaccines, gene therapy, oncolytic viruses
Mammalian, insect, avian and other animal cells for adherent and suspension culture
Scalability from discovery to commercial manufacturing
The scale-X technology was designed to achieve cost-effective large capacity production. Integrated into the NevoLine™ biomanufacturing platform, the scale-X nitro bioreactor enables the future of large-scale viral production.
The scale-X hydro and carbo systems offer scale-down models suited to meet smaller production demands.
WATCH & LISTEN
scale-X carbo bioreactor system
Bench-scale automated cell culture system for expression and concentration of viral drug substance, featuring a single-use bioreactor offering 10 to 30 m² growth surface.
The scale-X carbo system is suited for rapid process development and cost-effective clinical production.
CLICK & LEARN
Reinventing benchtop production
Novel structured fixed-bed design ensuring homogeneous cell and media distribution, offering 10 and 30 m² growth surface.
Ease of use
Single-use bioreactor with pre-assembled and guided tubing manifolds for easy setup. Quick access to key process controls parameters and user-friendly operations.
Unique fixed-bed sampling for direct cell monitoring and harvest time determination
In-line product concentration
Novel process design coupling high-density bioreactor with in-line product concentration, delivering concentrated harvest for streamlined downstream operations.
Advanced process control functionalities for protocol execution and standard parameter monitoring, enabling increased reproducibility & reliability.
Structured fixed-bed design ensures predictable behavior for seamless scale-up throughout the scale-X range.
Homogeneous cell distribution delivers reproducible performance coupled with cell sampling for direct monitoring.
Low footprint, integrated system produces high cell densities and viral titers to optimize capital investment and reduce operating costs.