Comparison between scale-X™ bioreactors and microcarrier cultivations
In viral vaccines production, anchorage-dependent cell lines, such as Vero cells are commonly used. Most viral vaccine manufacturing processes are therefore based on surface-dependent cell platforms. Typical cultivation systems such as roller bottles, multi-tray cell culture dishes and microcarrier bioreactors have constraints for large-scale production.
To overcome potential scale-up limitations and to ease manufacturing, fixed-bed bioreactors are a valuable alternative.
In comparison to randomly packed fabric strips found in commonly used fixed-bed bioreactors, the proprietary scale-X™ technology uses a structured, spiral wound fixed-bed to reduce local over compaction and dead zones, while making optimal usage of available surface area with high batch-to-batch reproducibility.